--- title: "Science 201: Enzyme activity and the power of powder" description: Factors that support digestive enzyme efficacy and their ability to break down FODMAPs most efficiently image: https://providers.fodzyme.com/hubfs/201-1.png --- [Skip to content](https://providers.fodzyme.com/blog/enzyme-activity#main-content) [![FODZYME®](https://providers.fodzyme.com/hubfs/Group%201686563727.svg)](https://providers.fodzyme.com/clinician-partners) - [WEBINARS](https://providers.fodzyme.com/ceu-webinars) - [HANDOUTS](https://providers.fodzyme.com/handouts-resources) - [RESEARCH](https://providers.fodzyme.com/research-brief) Open main navigation Close main navigation - [WEBINARS](https://providers.fodzyme.com/ceu-webinars) - [HANDOUTS](https://providers.fodzyme.com/handouts-resources) - [RESEARCH](https://providers.fodzyme.com/research-brief) - [GET PATIENTS STARTED](https://providers.fodzyme.com/get-patient-started) [GET PATIENTS STARTED](https://providers.fodzyme.com/get-patient-started) Dec 17, 2024, 10:06:11 AM # Science 201: Enzyme activity and the power of powder ![Picture of Jocelyn Wells, MS, RDN](https://providers.fodzyme.com/hs-fs/hubfs/Headshot%20(1)-1.png?width=50&name=Headshot%20(1)-1.png) [Jocelyn Wells, MS, RDN](https://providers.fodzyme.com/blog/author/jocelyn-wells-ms-rdn) Share: [facebook-f icon](http://www.facebook.com/share.php?u=https://providers.fodzyme.com/blog/enzyme-activity) [linkedin-in icon](http://www.linkedin.com/shareArticle?mini=true&url=https://providers.fodzyme.com/blog/enzyme-activity) [Twitter icon](https://twitter.com/intent/tweet?url=https://providers.fodzyme.com/blog/enzyme-activity) [pinterest-p icon](http://pinterest.com/pin/create/link/?url=https://providers.fodzyme.com/blog/enzyme-activity) [envelope icon](mailto:?body=https://providers.fodzyme.com/blog/enzyme-activity) #### The most important factors that support enzyme efficacy and FODMAP breakdown One of our favorite questions to be asked is about FODZYME®'s enzyme activity and why FODZYME® is a powder. The answers involve a return to biochemistry principles and a discussion on our peer-reviewed research. Because we're all scientists and educators at heart, let's dive in so you can help patients understand this nuanced topic, too. ## **What is enzyme activity?** Enzyme activity refers to the rate at which a specific enzyme catalyzes a particular biochemical reaction. It indicates the amount of enzyme required to convert one micromole of substrate per minute under standard conditions and is typically expressed in International Units (U). Enzyme activity units correspond to the substrate they target. For instance, enzymes that target Galacto-Oligosaccharides (GOS) are measured in Galactosidase Units (GALUs), while those targeting lactose are quantified in Acid Lactase Units (ALUs). ## **Factors that influence enzyme activity** **![Factors that influence enzyme activity](https://providers.fodzyme.com/hs-fs/hubfs/2-Dec-26-2024-06-23-56-8436-PM.png?width=899&height=470&name=2-Dec-26-2024-06-23-56-8436-PM.png)** Temperature, pH, time, enzyme preparation characteristics, the presence of other substances and the mode of administration all influence [enzyme activity](https://pmc.ncbi.nlm.nih.gov/articles/PMC4692135/). While activity units provide one method of assessing how digestive enzymes can help break down FODMAPs, they can be an unreliable metric due to variations in how they're measured and how the enzymes are utilized. FODZYME®'s mode of administration as a powder is designed with this knowledge: how enzymes are applied to food greatly influences their activity and therefore their efficacy. ## **Measuring the efficacy fructan hydrolase** FODZYME®'s fructan hydrolase is a novel and first of its kind digestive enzyme. In fact, it is the only enzyme that targets the broad spectrum of fructans, including inulin, levan and FOS. This means there is no standard activity unitestablished by the scientific community to quantify the activity of enzymes targeting fructans — at least not yet! A more accurate way to evaluate a digestive enzyme than using enzyme activity is to simulate passage through the digestive tract. With a simulated digestive environment, the amount of FODMAPs broken down at each stage of digestion can be directly quantified. This method is precisely how we assessed FODZYME®'s efficacy at fructan break down. Through our peer-reviewed [research](https://www.sciencedirect.com/science/article/pii/S2772572322001844), we demonstrated FODZYME®'s ability to break down 90% of a 3g dose of [fructan](https://providers.fodzyme.com/research-brief) under simulated gastric conditions (that's 6 garlic cloves worth!). ![FODZYME digestive enzymes for FODMAPs](https://providers.fodzyme.com/hs-fs/hubfs/3-Dec-26-2024-06-23-57-5582-PM.png?width=690&height=361&name=3-Dec-26-2024-06-23-57-5582-PM.png) ## **So how much enzyme activity is in FODZYME®?** We used findings from this research and common FODMAP tolerance thresholds to establish the recommended FODZYME® dose. Each dose of FODZYME® contains as much, and in many cases more, GALUs and ALUs as common lactose and GOS-targeting digestive enzyme products. Help your patients get started with FODZYME®. We offer personalized support to ensure all their questions on dosing and administration are answered. [![GET PATIENTS STARTED](https://no-cache.hubspot.com/cta/default/48211902/interactive-184471325594.png)](https://providers.fodzyme.com/hs/cta/wi/redirect?encryptedPayload=AVxigLJg%2FU2ev1WvE7f2g1cUnwvfYOpvB8TuAznO9frddxBYh0%2BKblxmPCv09oxeIjGxSPf92NB%2BPVZJMOfbHwjlyq2abOsIp4cFsxrForMnSDahCBPTbA3j3hovFUmHe7YgEm428LVTjT3X%2FdShjC%2FIdOnkZvvGg0fSzCYR33DSY%2FDTYwbCKG3buVDRSPCbm4WZ%2FCtlf1Q%3D&webInteractiveContentId=184471325594&portalId=48211902) PS — another common question we hear is: how do our stick packs get their 33% extra enzymatic activity? The answer: they have 33% more [enzyme powder](https://fodzyme.com/products/fodzyme) by volume than a scoop from our Home Kit. The enzyme blend in both is the same! ## Related posts [![](https://providers.fodzyme.com/hs-fs/hubfs/Website%20-%20Body%20images/FODZYME%20on%20ravioli-1-1.png?height=200&name=FODZYME%20on%20ravioli-1-1.png)](https://providers.fodzyme.com/blog/ddw-2026-takeaways) ## [DDW 2026 takeaways](https://providers.fodzyme.com/blog/ddw-2026-takeaways) Our FODZYME clinician team attended Digestive Disease Week 2026, one of the biggest conferences in... [Read more](https://providers.fodzyme.com/blog/ddw-2026-takeaways) [![](https://providers.fodzyme.com/hs-fs/hubfs/Website%20-%20Body%20images/FODZYME%20on%20ravioli-1-1.png?height=200&name=FODZYME%20on%20ravioli-1-1.png)](https://providers.fodzyme.com/blog/food-the-main-course-2026-takeaways) ## [FOOD: The Main Course 2026 takeaways](https://providers.fodzyme.com/blog/food-the-main-course-2026-takeaways) Our FODZYME clinician team attended FOOD: The Main Course 2026, a conference that focuses on... [Read more](https://providers.fodzyme.com/blog/food-the-main-course-2026-takeaways) [![Science 101: Digestive enzymes for FODMAPs](https://providers.fodzyme.com/hs-fs/hubfs/101.png?height=200&name=101.png)](https://providers.fodzyme.com/blog/digestive-enzymes-101) ## [Science 101: Digestive enzymes for FODMAPs](https://providers.fodzyme.com/blog/digestive-enzymes-101) Digestive enzymes can be important in managing FODMAPs intolerances. Read on to learn when and why... [Read more](https://providers.fodzyme.com/blog/digestive-enzymes-101) *\*These statements have not been evaluated by the Food and Drug Administration. 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